Biomedical Engineering, Duke University

137 11275
Position ID:Duke-BME-IMMUNOENGINEERINGPOSTDOC [#11275, Bursac Postdoc2]
Position Title: Postdoctoral Fellow in Immunoengineering for Muscle Regeneration
Position Type:Postdoctoral
Position Location:Durham, North Carolina 27708, United States [map]
Subject Area: Biomedical Engineering / Cellular Engineering
Appl Deadline:2019/03/01 (posted 2018/06/07, listed until 2019/03/01)
Position Description:    

Postdoctoral Fellow in Immunoengineering for Muscle Regeneration

A postdoctoral position is immediately available in the Bursac lab (http://bursaclab.pratt.duke.edu/) to study mechanisms of heteroceullular interactions between rat or human myogenic progenitors and immune system cells in the context of muscle injury and regeneration. Three-dimensional rat and human tissue-engineered organoid cultures of functional skeletal muscle (“myobundles”) will be made from myogenic progenitors co-cultured with bone marrow- or blood-derived macrophages. Roles of immune system cells in skeletal muscle regeneration will be studied after the induction of muscle injury in vitro and in vivo. Whole transcriptome and epigenetic analyses and molecular and pharmacological manipulations will be performed to engineer macrophages into pro-regenerative cells. Most promising therapeutic candidates will be validated in animal models of volumetric muscle loss in vivo.

Qualifications include PhD in cell and molecular biology, biomedical engineering, or other relevant areas of biomedical sciences. The ideal candidate will be highly self-motivated and possess strong training in skeletal muscle biology, cell and molecular biology, tissue engineering, biochemical and histological techniques. Candidates with experience in in vivo models of muscle injury and disease and genome editing technologies will be given priority. Postdoctoral fellows are expected to publish research findings in peer-reviewed journals, participate in conferences for the intellectual exchange of research ideas, engage in existing and new collaborations within and outside Duke University, and assist with training of undergraduate and graduate students, as needed. The training environment of the Bursac group is highly interdisciplinary and provides ample opportunities for scientific growth and pursuit of both academic and industry careers. Duke University is an equal opportunity employer. Interested candidates should send their resume, statement of research goals, and names of three reference writers to Dr. Nenad Bursac (nbursac@duke.edu).

Duke University is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status. Duke also makes good faith efforts to recruit, hire, and promote qualified women, minorities, individuals with disabilities, and veterans.


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