Duke University, Molecular Genetics and Microbiology

Position ID:Duke-MGM-POSTDOC [#11295, Cullen62018]
Position Title: Postdoctoral Associate
Position Type:Postdoctoral
Position Location:Durham, North Carolina 27710, United States [map]
Subject Areas: Molecular Biology
Appl Deadline: finished (2018/06/12, finished 2018/12/07)
Position Description:    

*** this position has been closed. ***

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 Fully Funded Postdoctoral Position Working on Viral Epitranscriptomics While it has been known for some time that both cellular and viral mRNAs are subject to post-transcriptional modifications that do not change their inherent coding capacity, the importance of these “epitranscriptomic” changes as regulators of gene expression has only recently come into focus. The most prevalent epitranscriptomic mark is addition of a methyl group to the N6 position of adenosine (m6A) and this modification is not only essential for embryonic viability and development in both plants and animals but also greatly influences viral replication, as documented in recent publications from this laboratory (1, 2) and discussed in more detail in a review from my group (3). We have also recently begun to investigate other epitranscriptomic marks found on viral RNAs, including m5C and 2’OMe. The field of viral epitranscriptomics, while clearly important for understanding viral gene regulation, is nevertheless currently at a very early stage of development. As a result, this area of research offers a tremendous opportunity for an ambitious individual to contribute to an emerging but clearly important area of research that they eventually will be able to take with them when they start their own research group. In the interim, the Cullen laboratory has a long record of high productivity (current ISI h index 105), is well funded and has a history of training post-docs, such as Michael Malim at King’s College, Paul Bieniasz at HHMI and, more recently, Rebecca Skalsky at OHSU, who have gone on to successful independent careers, many in academic research. Candidates should be less than two years out from their Ph.D and should have documented expertise in the fields of virology and/or molecular biology. 1. Kennedy EM, Bogerd HP, Kornepati AV, Kang D, Ghoshal D, Marshall JB, Poling BC, Tsai K, Gokhale NS, Horner SM, Cullen BR. (2016) Posttranscriptional m6A editing of HIV-1 mRNAs enhances viral gene expression. Cell Host Microbe; 19: 675-685. 2. Courtney, David G., Kennedy, Edward M., Dumm, Rebekah E., Bogerd, Hal P., Tsai, Kevin, Heaton, Nicholas S. and Cullen, Bryan R. (2017) Epitranscriptomic enhancement of influenza A virus gene expression and replication. Cell Host & Microbe, 22: 377-386. 3. Kennedy EM, Courtney DG, Tsai K, Cullen BR. (2017) Viral epitranscriptomics. Journal of Virology 91, e02263-16.

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Contact: Dr. Bryan Cullen, 919-684-3369, 919-684-2790 (fax)
Email: email
Postal Mail:
Duke University Medical Center, Box 3025
213 Research Dr., Room 0036 CARL Building
Durham, NC 27710
Web Page: https://sites.duke.edu/cullenlaboratory/

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