Molecular Biology & Genetics, Cornell University

Position ID:Cornell-MBG-POSTDOC1 [#11375, WDR-00015570]
Position Title: Postdoctoral Associate
Position Location:Ithaca, New York 14853, United States [map]
Subject Areas: Cryo-electron Microscopy
Cellular and Molecular Biology
Appl Deadline:2018/10/01 (posted 2018/07/05)
Position Description:    

The Kellogg laboratory in the Molecular Biology and Genetics Department at Cornell (Ithaca campus, starting October 1 2018), seeks a talented and motivated postdoc to study genome integrity using high-resolution cryo-EM.

The Kellogg laboratory combines protein modeling and design (using Rosetta) with high-resolution cryo-EM. This powerful approach will be used to answer questions in the field of genome organization and remodeling. Successful outcomes will provide mechanistic understanding of the protein-nucleic acid interactions that drive molecular function. Elizabeth (Liz) Kellogg did her postdoc with Eva Nogales at UC Bekeley with an emphasis on high-resolution single-particle cryo-EM. Most notably, she obtained the first structure of the transiently structure protein tau (normally classified as an intrinsically disordered protein) in its physiological state bound to microtubules. This structure was made possible by her use of sophisticated computational modeling tools (Rosetta) in which she is an expert, having completed her PhD in David Baker’s lab at the University of Washington. While at University of Washington, Liz Kellogg authored several highly-cited new modules in Rosetta for estimating protein stability and dynamics. The Kellogg lab a is fast-paced environment and is being outfitted with state-of-art equipment. Cornell university has recently acquired a high-end electron microscope (Arctica with K3 or equivalent + energy filter) with support staff to oversee microscope maintenance. In additional to ample access to this high-end microscope, trainees will have ample access to screening microscopes and will receive hands-on training on all aspects of single-particle cryo-EM and computational techniques, from image-processing to molecular modeling. Strong expertise in biochemistry (and in particular eukaryotic expression systems) and a desire to utilize and develop cutting-edge techniques in cryo-EM are required. Demonstrated practical experience with cryo-EM is a big plus. Excellent communication skills and collaborative attitude are essential. The postdoc will play a crucial role in shaping cryo-EM at Cornell and can expect a stimulating, supportive, and creative research environment not only within the lab but across departments. Applicant must have Ph.D. or equivalent degree in biochemistry or related field; degree may be anticipated but must be granted by the start date.

Diversity and Inclusion are a part of Cornell University’s heritage. We are a recognized employer and educator valuing AA/EEO, Protected Veterans and Individuals with Disabilities. Cornell University is an innovative Ivy League university and a great place to work. Our inclusive community of scholars, students, and staff impart an uncommon sense of larger purpose, and contribute creative ideas to further the university's mission of teaching, discovery, and engagement.

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Further Info:
Molecular Biology & Genetics
107 Biotech Building
Cornell University
Ithaca, NY 14853

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