Cornell University, LASSP/Physics

460 15329
Position ID:Cornell-LASSP-POSTDOC1 [#15329]
Position Title: Postdoctoral Position: X-ray and Electron Based Methods for Probing Biomolecular Structure and Function
Position Type:Postdoctoral
Position Location:Ithaca, New York 14853, United States [map]
Subject Areas: Physics / Biological Physics, Biophysics, Physics, Soft Condensed Matter Theory
Appl Deadline:2020/01/31 11:59PMhelp popup finished (2020/01/13, finished 2020/08/02, listed until 2020/05/15)
Position Description:    

*** this position has been closed, and no new applications is accepted. ***

Applications are invited for one or two postdoctoral positions in development of experimental and computational/analysis methods for X-ray crystallography and small-angle X-ray scattering of biomolecules, in the development of experimental methods for cryo-electron microscopy, and in fundamental studies of ice nucleation, growth, and aqueous glass formation. The group of Prof. Robert Thorne at Cornell University studies a variety of biological, chemical, and materials physics problems relevant in probing and understanding biomolecular structure and function, and develops new methods for synchrotron X-ray and electron diffraction-based study of biomolecular systems. Our emphasis is on fundamental understanding and methods rather than on the function of specific biomolecular systems. Methods and tools we have developed are used by structural biologists around the world. Information on our current and past projects is available at

The postdoctoral position(s) will focus on developing and applying tools and methods for variable temperature and time-resolved crystallography, for cryogenic and time-resolved variable-temperature small-angle X-ray scattering, for single-particle cryo-electron microscopy, and for interpreting the resulting data to extract information about biomolecular structure, function, and energy landscapes. These efforts will include supporting experiments and modeling of ice nucleation, growth, and glass formation in aqueous solutions. They will allow fundamental biophysical questions regarding enzymatic mechanisms, protein folding, protein evolution, allostery, and solvent structure and interactions to be addressed.

The work will make extensive use of the highly flexible facilities for X-ray science available at the Cornell High-Energy Synchrotron Source (CHESS) (, and the outstanding microbeam capabilities at NSLS-II. 

The work may involve CAD design and microfabrication (using Cornell’s outstanding Nanofabrication Facility (, X-ray data collection (at CHESS, NSLS, or APS), electron diffraction data collection and analysis using Cornell facilities, laboratory-based experiments, protein expression and purification, and modeling and analysis of data. The postdoctoral associate(s) will be expected to collaborate with CHESS staff scientists and other members of the structural biology and X-ray science communities at Cornell, and to assist in supervising graduate and especially undergraduate students.  

Applicants should have a Ph.D. in physics, biophysics, applied physics, structural/molecular biology, chemistry, materials science, or related fields.

The initial Postdoctoral Associate appointment will be for one year, with the expectation for renewal for at least one additional year.  Start dates are flexible and can be as early as March 2020.

Application material should be submitted to Academic Jobs Online. Complete applications will include a brief cover lettera CV, a detailed summary of research experience and interests, and three letters of recommendation. Recommendation letters, if not initially provided, will be requested after application screening. 

Diversity and Inclusion are a part of Cornell University’s heritage. The College of Arts and Sciences at Cornell embraces diversity and seeks candidates who will create a climate that attracts students and faculty of all races, nationalities, and genders. We strongly encourage women and underrepresented minorities to apply. Cornell University is a recognized EEO/AA employer and educator, valuing AA/EEO, Protected Veterans, and Individuals with Disabilities. 

For further information, please contact Prof. Robert E. Thorne at

Application Materials Required:
Submit the following items online at this website to complete your application:
And anything else requested in the position description.

Further Info:
529A Clark Hall
Cornell University
Ithaca, NY 14853

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