Department of Hematology, St. Jude Children's Research Hospital

2634 8506
Position ID:St. Jude Children's Research Hospital-Department of Hematology-POSTDOC [#8506]
Position Title: Postdoctoral Fellow in CRISPR-Cas Genome Engineering for Therapeutics
Position Type:Postdoctoral
Position Location:Memphis, Tennessee 38105, United States [map]
Subject Area: Hematology Oncology
Appl Deadline: finished (posted 2016/11/04)
Position Description:    

*** The account for Department of Hematology, St. Jude Children's Research Hospital has expired. ***

The Tsai Laboratory is seeking dynamic and creative candidates for a fully supported postdoctoral fellowship on gene editing technologies for therapeutic treatment of genetic disorders.

Programmable RNA-guided CRISPR-Cas nucleases, adapted from bacterial adaptive immune systems, are transforming both basic biological research and genomic medicine.

You will have the opportunity to lead new projects in this exciting space such as:

• Developing improved genomic methods to define and measure gene editing “off-target” effects
• Protein engineering of CRISPR-Cas nucleases to direct DNA- repair pathway choice away from error-prone non-homologous end-joining (NHEJ) and towards precise homology-directed repair (HDR) for gene correction
• Conducting high-throughput CRISPR-Cas screening for novel genetic contributors to fetal hemoglobin switching
• Developing novel strategies for allele-specific editing in hematopoietic stem cells (HSCs) of genetic mutations that cause sickle cell disease and other hematological disorders

In this position, you will gain extensive experience and training in gene editing, protein engineering, and high-throughput genome biology.

Successful applicants will have a strong publication record, excellent writing skills, and a Ph.D. or equivalent degree in molecular biology, cell biology, genetics, genomics, or a related area. To succeed in this position, you will have a strong molecular and cell biology background, with an emphasis on molecular cloning and transfection of mammalian cells. If you have additional experience with genome editing, hematopoietic stem cells, next-generation sequencing, protein purification, or automated liquid handling you are strongly encouraged to apply by e-mailing with a cover letter and CV.

About St. Jude
There’s a reason St. Jude Children’s Research Hospital is consistently ranked on Fortune Magazine’s “100 Best Places to Work For” list. At our world-class pediatric research hospital, every one of our professionals share our commitment to make a difference in the lives of the children we serve. There’s a unique bond when you’re part of a team that gives their all to advance the treatments and cures of pediatric catastrophic diseases. The result is a collaborative, positive environment where everyone, regardless of their role, receives the resources, support and encouragement to advance and grow their careers.

Interested applicants are encouraged to apply for job 35958 at

Contact Information
Shengdar Q. Tsai, Ph.D
Department of Hematology
St. Jude Children’s Research Hospital


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Contact: Shengdar Q. Tsai, Ph.D
Email: email
Postal Mail:
262 Danny Thomas Place, Memphis, TN 38105
Web Page:

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