Department of Immunology, Duke University

Position ID:Duke-Immunology-PA [#11288, Chan]
Position Title: Postdoctoral Associate - Immunology
Position Location:Durham, North Carolina 27710, United States [map]
Subject Area: Immunology
Appl Deadline:2018/07/31 (posted 2018/06/11, listed until 2018/07/31)
Position Description:    

A postdoctoral position is available in the laboratory of Dr. Francis Chan, PhD, in the Department of Immunology at Duke School of Medicine. The lab is interested in how cell death and inflammation interact with one another in the context of host defense against pathogens and auto-inflammatory diseases. We use a two-pronged approach to interrogate our scientific questions. We analyze basic signaling mechanisms in necroptosis and innate inflammation using biochemical, cell biological and biophysical approaches. We then leverage the knowledge gained from the biochemical studies to create mouse models to test the relevance of these signaling processes in pathogen infection and inflammatory diseases. There are multiple project possibilities within this general concept.

The ideal candidate will be someone who loves a challenge and is able to work in an independent but collaborative manner. He/she should have a Ph.D. or M.D. degree in life science, possess good command of knowledge in immunology and cell signaling, and proficiency in standard molecular, biochemical and immunological techniques.

Durham is a city with rich history and emerging interests. It is part of the Research Triangle Park (RTP), a private, nonprofit technology park offering expertise in microelectronics, telecommunications, biotechnology, pharmaceuticals and environmental sciences. Durham offers affordable living in an urban setting. With plenty of museums, a strong music culture, and abundant green space, it is one of the most desirable places to work and live in the US.

Representative publications 1. Moriwaki K, et al. Distinct kinase-independent role of RIPK3 in CD11c+ mononuclear phagocytes in cytokine-induced tissue repair. Cell Reports 2017 Mar 7;18(10):2441-2451. 2. Galluzzi L, et al. Necroptosis: Mechanisms and Relevance to Disease. Ann. Rev. Pathol. 2017 Jan 24;12:103-130. 3. Farias Luz N, et al. RIPK1 and PGAM5 control Leishmania replication through distinct mechanisms. J Immunol. 2016 Jun 15; 196(2):5056-63. 4. Mandal, P., et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell 2014 Nov, 56: 481-95. 5. K. Moriwaki, et al. The Necroptosis Adaptor RIPK3 Promotes Injury-Induced Cytokine Expression and Tissue Repair. Immunity 2014 Oct, 41:567-78. 6. J. Li, et al. The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis. Cell 150, 339-350 (2012). 7. H. Zhang, et al. Functional Complementation between FADD and RIP1 in Embryos and Lymphocytes. Nature 471: 373-6 (2011). 8. Y. Cho, et al. Phosphorylation-Driven Assembly of RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-induced Inflammation. Cell 137, 1112-23 (2009).

Duke University is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status. Duke also makes good faith efforts to recruit, hire, and promote qualified women, minorities, individuals with disabilities, and veterans.


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Further Info:
email
919-684-5726
 
Department of Immunology
Duke University
P.O.Box 3010
Durham, NC 27710

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