Duke University, Biology
Position Description
A postdoctoral research position is available immediately to join an interdisciplinary project focused on gibberellin (GA) signaling and transcriptional regulation in plants. We seek a highly motivated researcher with a strong background in protein chemistry, molecular genetics, genomics, and/or plant development. GA perception by its nuclear receptor, GIBBERELLIN INSENSITIVE DWARF1 (GID1), triggers polyubiquitination and proteasomal degradation of the master growth regulators DELLA proteins via the SCFSLY1/GID2 E3 ubiquitin ligase complex. DELLA genes are known as “Green Revolution” genes, as dominant mutations confer semi-dwarfism and significantly increased crop yields through reduced GA responsiveness. DELLA proteins function as central signaling hubs, interacting with diverse transcription factors (TFs) to integrate hormonal and developmental signals. Recent studies show that DELLAs associate with both activated and repressed promoters, and that TF–DELLA–histone H2A complexes at target chromatin are essential for their regulatory activity. However, how DELLAs achieve interaction specificity and act as transcriptional coactivators or corepressors at distinct genes remains unclear. This project uses structural, biochemical, and genomics approaches to address these questions and uncover fundamental mechanisms of plant growth regulation. Clear evidence of past research productivity is required, and strong communication skills are expected. This position requires a PhD. To apply, candidates should submit a cover letter, curriculum vitae, and contact information for three references to Professor Tai-ping Sun, email address: tps@duke.edu.Duke is an Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, (including pregnancy and pregnancy related conditions), sexual orientation, or military status.
Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.
Application Materials Required:
- Cover letter
- Curriculum Vitae
- Three references (no actual letters, just names and email addresses
)
Further Info: