University of Maryland Baltimore, Department of Microbial Pathogenesis

Position ID:University of Maryland Baltimore-Department of Microbial Pathogenesis-POSTDOC [#14194]
Position Title: Postdoctoral Fellow – Vaccines for Diarrheal Diseases
Position Type:Postdoctoral
Position Location:Baltimore, Maryland 21201, United States
Subject Areas: Biological Sciences
Molecular Biology
Microbiology
Immunology
Appl Deadline:2019/09/03help popup
Position Description:    

The Department of Microbial Pathogenesis at the University of Maryland School of Dentistry is recruiting a highly motivated postdoctoral fellow to investigate attenuated live vaccine strains of Shigella for protection against diarrheal disease. This project is funded by the Department of Defense and seeks to develop next-generation vaccine strains based on lipid A structural modification.

The purpose of this research is to determine whether alternate lipid A mutants can reduce the endotoxicity of the current live attenuated Shigella vaccines and enhance intrinsic adjuvanticity. For this work, we will utilize Bacterial Enzymatic Combinatorial Chemistry (Patent: PCT/US2014/022121) to harness the native lipid A biosynthetic enzymes and pathways from diverse bacterial backgrounds to produce molecules that stimulate specific components of an immune response (PMID: 28487429) with the goal to decrease the reactogenicity seen at high doses with live Shigella vaccines (PMID: 18468742). The successful outcome of this work could present immediate benefits and long-term protection from most Shigella infections for travelers and children. This is a highly collaborative project involving multiple investigators at the University of Maryland, Baltimore (UMB) and Walter Reed Army Institute of Research (WRAIR). The ideal candidate will have experience with molecular microbiology techniques, rodent vaccination using multiple routes and antemortem sample collection, basic immunological profiling assays (ELISA, CBA, multicolor flow cytometry, etc.), virulence assay methods (plaque, etc.), and a strong analytical background.

The University of Maryland, Baltimore (UMB) is a world-renowned hub of microbiology, immunology, and vaccine research. The downtown Baltimore campus of the University of Maryland includes the Schools of Dentistry, Medicine, Law, Social Work, and others, making for a rich campus community with extensive resources. Postdoctoral resources and professional development opportunities are extensive at the UMB. Centrally located, the campus is close to the excitement of Baltimore’s Inner Harbor, Camden Yards, M&T Bank Stadium, and is easily reachable from public transportation. UMB is an Equal Opportunity Employer; minorities, women, individuals with disabilities, and protected veterans are encouraged to apply. To apply, please send a current, dated, and signed Curriculum Vitae, contact information for three references, and a two-page statement (maximum) of research experiences, interest, and goals to:

Dr. Robert K. Ernst, PhD Professor and Vice Chair Department of Microbial Pathogenesis University of Maryland School of Dentistry e: rkernst[at]umaryland[dot]edu


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Baltimore, MD 21201

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