Duke University, Biomedical Engineering

137 19956
Position ID:Duke-BME-PDABURSAC10721 [#19956]
Position Title: Postdoctoral Associate
Position Type:Postdoctoral
Position Location:Durham, North Carolina 27708, United States [map] sort by distance
Subject Area: Biomedical Engineering / Biomedical Engineering
Appl Deadline:2021/12/31 11:59PMhelp popup finished (2021/10/07, finished 2022/07/02, listed until 2022/04/01)
Position Description:    

*** this position has been closed and new applications are no longer accepted. ***

Postdoctoral Fellows in Heart and Muscle Regeneration

Multiple postdoctoral positions are immediately available in the Bursac Lab at Duke University (http://bursaclab.pratt.duke.edu/). The focus of the work will be on the use of human induced pluripotent stem cells (hiPSCs) to study skeletal and cardiac muscle biology, disease, and regeneration. Specifically, patient-derived or genome-edited hiPSCs will be differentiated to form miniature human skeletal and cardiac muscle tissues (“myobundles and cardiobundles”). These organoids will be optimized to contain robust electrical and contractile function and will be further combined with hiPSC-derived endothelial, neuronal, and immune system cells of the same genetic background to develop more realistic, high-fidelity tissue on-a-chip disease models. The initial focus will be on the in vitro studies of genotype-phenotype relationships in Duchenne Muscular Dystrophy, Pompe disease, Dysferlinopathies, and Rheumatoid arthritis. Furthermore, small molecule genomic and pharmacological screens will be applied to discover new therapeutic targets for skeletal and cardiac muscle regeneration in reporter hiPSC lines generated by genome editing. The most promising gene and tissue engineering candidate therapeutic from these in vitro studies will be validated in animal models of myocardial infarction and skeletal muscle disease and injury in vivo. We use both small (mice, rats) and large (pig) animals in basic and pre-clinical research.

Qualified candidates should possess a PhD or MD/PhD degree in cell and molecular biology, biomedical engineering, or other relevant areas of biomedical sciences. The ideal candidates will be highly self-motivated and possess strong training in some or all of cell and molecular biology, tissue engineering, genome editing, biochemical and histological techniques. Candidates with experience in culturing and differentiation of human iPS cells into cardiomyocytes or skeletal muscle cells, genome editing (CRISPR), and in vivo models of cardiac or skeletal muscle injuries and disease will be given priority. Our group is a diverse and stimulating environment that provides excellent opportunities for scientific growth and pursuit of a variety of careers.

Duke University is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status.

Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas-an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.

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