Duke Health, Pediatrics/Koeberl/Medical Genetics/Medicine

Position ID:Duke Health-Pediatrics/Koeberl/Medical Genetics/Medicine-POSTDOC [#21862]
Position Title: Postdoctoral Fellow – Genome Editing and Small Molecule Therapy
Position Location:Durham, North Carolina 27710, United States [map] sort by distance
Subject Area: Molecular Biology & Genetics
Appl Deadline:2022/12/31 11:59PMhelp popup finished (2022/06/01, finished 2023/07/01, listed until 2022/12/31)
Position Description:    

*** this position has been closed and new applications are no longer accepted. ***

Postdoctoral position available immediately for research on genome editing in rare genetic diseases. Genome editing with adeno-associated virus vectors is a major focus of the laboratory. The project will include in vivo genome editing to treat glycogen storage disease (GSD), either GSD type Ia or Pompe disease. A second focus is to develop small molecules to stimulate autophagy and reverse the abnormalities of autophagy in GSD. New drug therapy for GSD will have implications for the treatment of more common conditions, including non-alcoholic fatty liver disease and diabetic nephropathy. Representative publications describe the scope of this project.1-6 Duke University features outstanding clinical and scientific resources with opportunities for local and international collaboration. This position will support an active collaboration with established genome editing, autophagy, and virology research groups. Candidates with molecular biology experience, and familiarity with viral vectors, immunology, and/or biochemistry are encouraged to apply. Ph.D. and/or M.D. required. The position is located in Dwight Koeberl’s laboratory in the Department of Pediatrics and Division of Medical Genetics, and the Molecular Genetics and Microbiology Department at Duke University.

Website: https://scholars.duke.edu/display/per3329362

Interested candidates should submit their electronic application to dwight.koeberl@duke.edu that should include: (1) the names of 3 references, and (2) an updated CV.

References 1 Farah, B. L. et al. Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency. J Hepatol 64, 370-379, doi:10.1016/j.jhep.2015.10.008 (2016). 2 Farah, B. L. et al. Hepatic mitochondrial dysfunction is a feature of Glycogen Storage Disease Type Ia (GSDIa). Sci Rep 7, 44408, doi:10.1038/srep44408 (2017). 3 Landau, D. J. et al. In Vivo Zinc Finger Nuclease-mediated Targeted Integration of a Glucose-6-phosphatase Transgene Promotes Survival in Mice With Glycogen Storage Disease Type IA. Mol Ther 24, 697-706, doi:10.1038/mt.2016.35 (2016). 4 Waskowicz, L. R. et al. Bezafibrate induces autophagy and improves hepatic lipid metabolism in glycogen storage disease type Ia. Hum Mol Genet 28, 143-154, doi:10.1093/hmg/ddy343 (2019). 5 Kang, H. R. et al. Bezafibrate Enhances AAV Vector-Mediated Genome Editing in Glycogen Storage Disease Type Ia. Mol Ther Methods Clin Dev 13, 265-273, doi:10.1016/j.omtm.2019.02.002 (2019). 6 Yavarow, Z. A. et al. Fenofibrate rapidly decreases hepatic lipid and glycogen storage in neonatal mice with glycogen storage disease type Ia. Hum Mol Genet 29, 286-294, doi:10.1093/hmg/ddz290 (2020).

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Application Materials Required:
Submit the following items online at this website to complete your application:
And anything else requested in the position description.

Further Info:
email address
Box 103856 DUMC
Durham, NC 27710