Duke University, Biostatistics & Bioinformatics

Position ID:Duke-Biostatistics & Bioinformatics-PD238523 [#26473]
Position Title: Postdoctoral Associate - Biostatistics & Bioinformatics
Position Type:Postdoctoral
Position Location:Durham, North Carolina 27710, United States [map] sort by distance
Subject Areas: Statistics
Computational Biology
Data Science
Appl Deadline:none (posted 2023/11/01)
Position Description:    

Postdoctoral Associate

We are looking for a postdoc in computational immunology to develop an in silico model of therapeutic interventions for prevention of congenital cytomegalovirus (cCMV) based on identified immune correlates of cCMV transmission and placental tissue models. The model will be calibrated from a uniquely large cohort of acutely CMV-infected pregnant women (n = 399) to predict the outcome of a CMV vaccine in protection against placental virus transmission, as well as the ability of maternal plasma antibodies to block virus spread at the maternal-fetal interface. Moreover, this model can be refined through the study of CMV replication in a placental organoid model, past and concurrent challenge models a non-human primate model. This work will build on an existing maternal/placental/fetal model developed by our group for CMV transmission in the Rhesus macaque model, and extend it by including specific immune responses, especially at the maternal-fetal interface, using neural differential equation approaches for model calibration. 

The postdoc will also receive training in immune data science, and the analysis of complex immunological data sets, and be part of a community of virologists, immunologists, statisticians, and mathematicians within the Duke Center for Human Systems Immunology.



Duke University is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status.

Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas-an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.


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Web Page: https://biostat.duke.edu/