University of Zurich, Department of Mathematical Modeling and Machine Learning

Position Description
The project
Our Sinergia consortium unites expertise at the University of Zurich (Mathematical Modeling & Machine Learning) and ETH Zurich (Department of Mathematics) to push the frontier of data‑driven decision support in large‑scale, real‑world systems under SNSF project “From Single‑Disease Research to Informed Machine Learning. We develop methods that combine reinforcement learning (RL) and large language models (LLMs) to optimize processes, automate design choices and reason about constraints under uncertainty. We will appoint up to two post‑doctoral researchers, each specializing in one of the complementary tracks below. The precise application domain will be defined in consultation with the successful candidates and our research partners in epidemiology and related fields.
Your role
Track A – RL / Optimization
Design, implement and evaluate RL frameworks for complex, high‑dimensional environments, leveraging simulation‑based optimization and digital‑twin testbeds
Explore multi‑agent or distributed training techniques to scale optimization across interacting subsystems
Collaborate with domain scientists to translate algorithms into prototype decision‑support tools
Track B – LLM / Knowledge‑Engineering
Develop and fine‑tune LLM pipelines that integrate structured reasoning tools (e.g. retrieval‑augmented generation, knowledge graphs, constraint parsers)
Build workflows for transparent explanation and evaluation of model decisions
Maintain and contribute to open‑source libraries that support reproducible research in the project
What we are looking for
Must‑have (both tracks)
- PhD (or equivalent) in computer science, applied mathematics, operations research, physics, statistics or a related field
- Documented, hands‑on track record of applying RL and/or LLMs to real‑world problems (publications, deployed systems, or open‑source artefacts)
- Excellent Python skills and familiarity with modern ML stacks (e.g. PyTorch, JAX, Hugging Face)
- Ability to thrive in an interdisciplinary environment and to communicate complex ideas clearly
- Prior experience in healthcare, epidemiology, or medical applications of machine learning or statistics (e.g., causal inference) is not required
Nice‑to‑have – Track A
- Experience with simulation‑based optimization or digital‑twin frameworks
- Familiarity with multi‑agent RL or distributed training
Nice‑to‑have – Track B
- Experience integrating LLMs with structured reasoning tools (RAG, KGs, constraint solvers)
- Track record of open‑source contributions to RL, LLM or optimization libraries
What we offer
- Fully funded positions (SNSF postdoctoral scale, approx. CHF 100k/year) within a vibrant, international research environment
- Mentoring by Nicola Serra (Mathematical Modeling & ML, UZH) and Alessio Figalli (Mathematics, ETHZ), together with the broader Sinergia team
- Close collaboration with partners in medicine, economics and computer science
- State‑of‑the‑art computing resources, a generous travel & training budget, and support for industry or clinical secondments
- A dynamic, family‑friendly workplace in Zurich with competitive Swiss salaries and an excellent quality of life
Application & contact
Please send a single PDF containing- a cover letter indicating which track you are applying for (RL/Optimization, LLM/Knowledge‑Engineering or both),
- CV
- publication list, and
- contact details of two referees
- Prof. Nicola Serra – nicola.serra@uzh.ch
- Prof. Alessio Figalli – figalli@math.ethz.ch
We are not accepting applications for this job through AcademicJobsOnline.Org right now. Please nicola.serra+sinergia@uzh.ch.
- Postal Mail:
- University of Zurich
Department of Mathematical Modeling and Machine Learning
Winterthurerstrasse 190
8057 Zürich
- University of Zurich
- Web Page: https://dm3l.uzh.ch