Duke University, Center for Advanced Genomic Technologies
Position ID:
Position Title:
Postdoctoral Associate
Position Type:
Other
Position Location:
Durham, North Carolina 27708, United States of America
Subject Area:
Appl Deadline:
(offers accepted posted 2024/10/24, listed until 2025/04/24)
Position Description:
Position Description
The Center for Advanced Genomic Technologies in the Pratt School of Engineering at Duke University. The Gersbach lab (Department of Biomedical Engineering) and Crawford lab (Department of Pediatrics) at Duke University are seeking a Postdoctoral scientist to work in the field of computational analysis of single cell multiome and CRISPR epigenome editing screen experiments. This position explores mechanisms of epigenetic establishment and impact on targeted/global gene expression patterns. Data will come from experiments using CRISPR/dCas9-based epigenome editing tools, high-throughput screening, and human induced pluripotent stem cells (hiPSCs) to model different cell types, phenotypes, and disorders. We are looking for a highly motivated and talented candidate (PhD in computational biology, statistics, genetics or related field) with excellent quantitative and dry lab skills. The successful candidate will be expected to develop and lead computational analyses of complex multiome and/or CRISPR screening datasets. The individual will be detail oriented, adhere to best practices, and manage several ongoing tasks with competing deadlines. This dry lab position will work with wet-lab graduate students and postdoctoral fellows. Therefore, we seek someone who can works well in a team-based setting. Required qualifications: 1. PhD degree in computational biology, genetics, statistics, or related discipline. 2. Self motivated and able to drive their own project. 3. Ability to work effectively in both a team setting and independently with minimum supervision. 4. Ability to execute appropriate computational and statistical analyses and present data in 5. Abililty to learn from existing literature to develop new methods and strategies to analyze complex datesets. 6. Strong oral and written communication skills. 7. Strong critical thinking skills and excellent attention to detail. 8. Must have advanced computational and statistical analysis skills. The following skills are highly desired (any combination): 1. Familiarity with NGS platforms and analysis of NGS data 2. Knowledge of workflows to analyze single cell and bulk sequencing data, including RNA-seq, DNA methylation, ChIP-seq, and ATAC-seq, CRISPR and RNAi perturbation screens 3. Ability to build predictive statistical and machine learning models that integrate multiple data types, including linear and nonlinear ML models 4. Ability to utilize publicly available datasets (e.g., DepMap, TCGA, ENCODE, GTEx, gnomAD, etc.)Duke University is an Affirmative Action/Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex, sexual orientation, or veteran status. Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas-an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values.
Application Materials Required:
Submit the following items online at this website to complete your application:
- Cover letter
- Curriculum Vitae
- Research statement
- Two reference letters (to be submitted online by the reference writers on this site
)
And anything else requested in the position description.
Further Info: